Thermo Fisher Scientific APP Monoclonal Antibody (OTI7G9), TrueMAB
APP 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI7G9). Western blot, IHC, ICC, Flow cytometry에 사용 가능. Human 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. Alzheimer’s disease 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7G9 |
| Immunogen | Full length human recombinant APP protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor involved in axonal transport of beta-secretase and presenilin 1. It plays important roles in neurite growth, neuronal adhesion, and axonogenesis. APP is a 100–140 kDa transmembrane glycoprotein with multiple isoforms generated by alternative splicing. Proteolytic cleavage by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques, a hallmark of Alzheimer’s disease. Abnormal APP regulation is also associated with Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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