Thermo Fisher Scientific TPMT Monoclonal Antibody (OTI2A2), TrueMAB
TPMT 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제, 0.73 mg/mL 농도. 인간 TPMT 재조합 단백질로 면역생성. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A2 |
| Immunogen | Full length human recombinant protein of human TPMT produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.73 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosuppressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease, and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs, and inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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