Thermo Fisher Scientific MCM10 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Peptide sequence:
PKLSALAEAK KLAAITKLRA KGQVLTKTNP NSIKKKQKDP QDILEVKERV

Sequence homology:
Cow: 77%
Dog: 86%
Horse: 93%
Human: 100%
Pig: 77%
Rabbit: 86%

Target Information

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and recruitment of other DNA replication-related proteins. This protein interacts with MCM2 and MCM6, as well as the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies in Xenopus suggest that chromatin binding of this protein at the onset of DNA replication occurs after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.