Thermo Fisher Scientific Estrogen Receptor alpha Monoclonal Antibody (8H9A10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15454 targets ESR1 in indirect ELISA and Western blot applications and shows reactivity with Human samples.
The immunogen used for this antibody is a purified recombinant fragment of ESR1 (aa130–339) expressed in E. coli.

Target Information

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
ERs regulate gene transcription through recruitment of coactivators or corepressors.
Two distinct forms exist, ER alpha (ESR1) and ER beta (ESR2), encoded by separate genes. Alternative splicing produces at least four ER-alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa).
ERs are widely expressed in diverse tissues, essential for sexual development and reproductive function, and also play roles in bone and other tissues. They are implicated in various pathological processes including breast cancer, endometrial cancer, and osteoporosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.