Thermo Fisher Scientific IL-6 Receptor Monoclonal Antibody (B-R6)
인간 IL-6 수용체(CD126)를 인식하는 Mouse monoclonal antibody (Clone B-R6). 다양한 응용(IHC, ICC, Flow, ELISA, IP, Neutralization)에 사용 가능. Protein A 정제, 1 mg/mL 농도, PBS buffer에 0.1% sodium azide 함유. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | 1 publication |
| Flow Cytometry (Flow) | 1:50 | 1 publication |
| ELISA | Assay-dependent | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Neutralization (Neu) | - | 2 publications |
| Miscellaneous PubMed (Misc) | - | 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B-R6 |
| Immunogen | CHO cells transfected with cDNA of the IL-6 receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | <0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2249244 |
Product Specific Information
- For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
- Mouse anti-Human CD126 antibody, clone B-R6, recognizes human Interleukin-6 receptor subunit alpha (CD126, IL-6R, or Membrane glycoprotein 80).
Target Information
Interleukin 6 receptor (IL6R), also known as CD126, is a type I cytokine receptor. It encodes a subunit of the IL-6 receptor complex, which plays a key role in cell growth, differentiation, and immune response. The IL6 receptor forms a complex with IL6ST (GP130), a receptor subunit shared by multiple cytokines. Dysregulation of IL6 and IL6R is associated with diseases such as multiple myeloma, autoimmune disorders, and prostate cancer. Alternatively spliced variants and a pseudogene on chromosome 9 have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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