Thermo Fisher Scientific CEP78 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.
• Application Note: For ICC, formaldehyde fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells.

Target Information

This gene encodes a centrosomal protein required for regulation of centrosome-related events during the cell cycle and for ciliogenesis. The encoded protein contains an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Mutations in this gene cause defects in primary cilia leading to retinal degeneration and sensorineural hearing loss, associated with cone-rod degeneration and Usher syndrome. Low expression of this gene correlates with poor prognosis in colorectal cancer patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.