Thermo Fisher Scientific CEP78 Polyclonal Antibody
CEP78 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, ICC/IF, IP에 사용 가능하며 비결합(Unconjugated) 상태로 제공. 세포주기 및 섬모 형성과 관련된 centrosomal 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 550 and 600 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- Application Note: For ICC, formaldehyde fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells.
Target Information
This gene encodes a centrosomal protein required for regulation of centrosome-related events during the cell cycle and for ciliogenesis. The encoded protein contains an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Mutations in this gene cause defects in primary cilia leading to retinal degeneration and sensorineural hearing loss, associated with cone-rod degeneration and Usher syndrome. Low expression of this gene correlates with poor prognosis in colorectal cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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