Thermo Fisher Scientific CEP78 Polyclonal Antibody
CEP78 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 면역세포화학(ICC/IF)에 적합. 비결합 액상 형태로 제공되며, 4°C 보관. 세포 주기 중 중심체 조절 및 섬모형성과 관련된 단백질 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Application Note:
For ICC, formaldehyde fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells.
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 550 and 600 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| Shelf Life | 1 year from date of receipt |
Target Information
The CEP78 gene encodes a centrosomal protein required for regulation of centrosome-related events during the cell cycle and for ciliogenesis. The encoded protein contains an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 at the distal end of the centriole. Mutations in this gene can cause primary cilia defects leading to retinal degeneration and sensorineural hearing loss, associated with cone-rod degeneration disease and Usher syndrome. Low expression of CEP78 is linked to poor prognosis in colorectal cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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