Thermo Fisher Scientific ALK Monoclonal Antibody (2A5)
인간 ALK 단백질을 인식하는 Mouse IgG1 단클론 항체입니다. ELISA에 최적화되어 있으며, 뇌 발달 관련 연구 및 ALK 변이 암 연구에 활용됩니다. PBS(pH 7.4) 용액 형태로 제공되며, -20°C에서 보관합니다.
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Applications
- ELISA (ELISA): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A5 |
| Immunogen | A synthetic peptide corresponding to human ALK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
TPQWQVRTLK DARFQDHQDH C
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene consisting of the ALK gene and the nucleophosmin (NPM) gene. The NPM-ALK fusion gene product is oncogenic. ALK is a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high similarity to LTK. It plays a key role in neuronal development and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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