Thermo Fisher Scientific Placental Alkaline Phosphatase Polyclonal Antibody
인체 PLAP에 특이적인 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 염증성 질환 및 생식세포 종양 연구에 유용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ALPP. Recombinant protein control fragment (Product #RP-98831). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790593 |
Product Specific Information
Immunogen sequence:
NWYSDADVPA SARQEGCQDI ATQLISNMDI
Target Information
Placental Alkaline Phosphatase (PLAP) plays a role in regulating specific inflammatory disease processes. There are four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney types. PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) occurring in the placenta during the third trimester of gestation. It is useful in identifying testicular germ cell tumors. PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of PLAP is matrix mineralization; however, mice lacking functional PLAP show normal skeletal development. PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects. The severity and onset depend on the specific mutation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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