Thermo Fisher Scientific CYP24A1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CYP24A1. Validated for ICC/IF at 0.25–2 µg/mL. Purified by antigen affinity chromatography, supplied in PBS with 40% glycerol. Suitable for research on vitamin D metabolism and calcium homeostasis.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CYP24A1 (Recombinant protein control fragment, Product #RP-105285) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663175 |
Product Specific Information
Immunogen sequence:
KEGYGLLILEG EDWQRVRSAF QKKLMKPGEV MKLDNKINEV LADFMGRIDE LCDERGHVED LYSELN
Highest antigen sequence identity to orthologs: mouse 81%, rat 79%.
Target Information
The CYP24A1 gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3 (the active form of vitamin D3) by hydroxylation of the side chain. By regulating vitamin D3 levels, this enzyme contributes to calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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