Thermo Fisher Scientific HRH4 Polyclonal Antibody
인간 및 비인간 영장류 반응성을 가진 HRH4 폴리클로날 항체로, IHC 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 제품. 히스타민 H4 수용체 연구용으로 적합하며, 장기 보관 시 -20°C에서 안정적.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 20 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 1st cytoplasmic domain of human HRH4 / Histamine H4 Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551219 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Monkey, Marmoset (100%)
- Bovine, Horse, Rabbit (94%)
- Gibbon, Mouse, Panda, Dog (89%)
Target Information
The Histamine H4 receptor has been reported in human peripheral blood leukocytes, bone marrow, colon, liver, lung, small intestine, spleen, testis, thymus, tonsil, and trachea.
Unlike the mouse H4 receptor, the human gene was not detected in the brain.
G-protein Coupled Receptors (GPCRs) are one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices and existing in both active and inactive forms. Activating ligands induce conformational changes that lead to signaling via G-proteins and downstream effectors.
Studies on GPCR regulation have significant implications for cellular physiology and drug development. Examples of GPCR-targeted pharmaceuticals include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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