Thermo Fisher Scientific HRH4 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 3.6 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human: 100%
• Monkey: 94%

Target Information

The Histamine H4 receptor is expressed in human peripheral blood leukocytes, bone marrow, colon, liver, lung, small intestine, spleen, testis, thymus, tonsil, and trachea. Unlike the mouse H4 receptor, the human gene is not detected in brain.

G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, sharing a structural motif of seven transmembrane helices and existing in active and inactive states. Ligand binding induces conformational changes leading to G-protein signaling and downstream effects. Negative regulation mechanisms of GPCRs have significant physiological implications and are a major focus in pharmacological research. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) exemplify successful therapeutic applications.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.