Thermo Fisher Scientific HRH4 Polyclonal Antibody
Human HRH4 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 0.1% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 3.6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 2nd extracellular domain of human HRH4 / Histamine H4 Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551218 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human: 100%
- Monkey: 94%
Target Information
The Histamine H4 receptor is expressed in human peripheral blood leukocytes, bone marrow, colon, liver, lung, small intestine, spleen, testis, thymus, tonsil, and trachea. Unlike the mouse H4 receptor, the human gene is not detected in brain.
G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, sharing a structural motif of seven transmembrane helices and existing in active and inactive states. Ligand binding induces conformational changes leading to G-protein signaling and downstream effects. Negative regulation mechanisms of GPCRs have significant physiological implications and are a major focus in pharmacological research. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) exemplify successful therapeutic applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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