Thermo Fisher Scientific HRH4 Polyclonal Antibody
Human HRH4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC, ICC/IF, ELISA 등에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. PBS 버퍼 및 0.1% sodium azide 포함, 4°C 또는 -20°C에서 안정적으로 보관 가능.
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Thermo Fisher Scientific HRH4 Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from C-terminus of human HRH4 / Histamine H4 Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551220 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human: 100%
- Gibbon, Monkey: 94%
Target Information
The Histamine H4 receptor has been reported in human peripheral blood leukocytes, bone marrow, colon, liver, lung, small intestine, spleen, testis, thymus, tonsil, and trachea.
Unlike the mouse H4 receptor, the human gene was not detected in brain.
G-protein Coupled Receptors (GPCRs) are among the largest families of signaling molecules, with over a thousand predicted members.
All GPCRs share a structural motif of seven membrane-spanning helices and exist in active and inactive conformations.
Activation by ligands triggers signaling via G-proteins and downstream effectors.
Negative regulation mechanisms of GPCRs play crucial roles in cellular physiology and pharmacological research.
Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), major treatments in mental health and allergy markets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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