Thermo Fisher Scientific TCTN3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TCTN3.

Target Information

TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 are not fully known, it shares 58% similarity with TCTN1. TCTN1 is expressed during embryonic development in regions participating in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later developmental stages, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.