Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI4B12), TrueMAB
Human GEMIN8 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. TrueMAB 포맷의 고순도 항체로 Affinity chromatography로 정제됨. PBS/BSA/glycerol 버퍼에 보관하며 -20°C에서 안정적 저장 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B12 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. This complex is crucial for splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of snRNA to create the core snRNP. In the cytosol, Sm proteins are held in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex dissociates CLNS1A and transfers Sm proteins to an SMN-Sm complex, triggering core snRNP assembly and nuclear transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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