Thermo Fisher Scientific TIMP2 Monoclonal Antibody (3A4), Biotin

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 4 publications 4 publications

Immunohistochemistry (IHC)

-

View 31 publications 31 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Bovine, Guinea pig, Human, Mouse, Rabbit, Rat

Published species

Bovine, Human, Mouse, Rabbit, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

3A4

Immunogen

A synthetic peptide from the N-terminal region of human TIMP-2 protein if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TIMP2,uniProtId:P16035-1,ncbiNodeId:9606,antigenRange:1,antigenLength:220,antigenImageFileName:MA5-12204_TIMP2_P16035-1_House_mouse.svg,antigenImageFileNamePDP:MA5-12204_TIMP2_P16035-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10985109

Product Specific Information

MA5-12204 targets TIMP-2 in IHC (P) and WB applications and shows reactivity with Bovine, Guinea Pig, Human, mouse, Rabbit, and Rat samples.

The MA5-12204 immunogen is a synthetic peptide from the N-terminal region of human TIMP-2 protein.

Target Information

TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.