Thermo Fisher Scientific Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (JB22-44)
Phospho-alpha Synuclein (Ser129) 특이적 재조합 단일클론 항체로 인간 시료에 반응합니다. Western Blot, IHC, ICC/IF에 사용 가능하며 고순도 Protein A 정제 제품입니다. 1 mg/mL 농도의 액상 형태로 -20°C에서 안정적으로 보관됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JB22-44 |
| Immunogen | Synthetic peptide within Human Phospho-alpha Synuclein (S129) aa 91–140 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848579 |
Product Specific Information
Positive Control: Hela, HUVEC, SH-SY-5Y, rat brain tissue, human kidney tissue, mouse brain tissue.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are implicated in Parkinson’s disease pathogenesis. Alpha-synuclein peptides are a major component of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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