Thermo Fisher Scientific Phospho-Bim (Ser44, Ser104) Polyclonal Antibody
인산화된 Bim 단백질(Ser44, Ser104)을 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot과 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 고순도 액상 형태로 제공되며 -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2L11 (Accession O43521), corresponding to amino acid residues around phosphorylated Ser104 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817372 |
Product Specific Information
Antibody detects endogenous levels of Bim only when phosphorylated at Thr104 (Isoform BimEL, O43521-1) or Thr44 (Isoform BimL, O43521-2).
Target Information
BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3) and interacts with BCL2, BCL2L1/BCL-X(L), and MCL1 to act as an apoptotic activator.
Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting roles in neuronal and lymphocyte apoptosis.
Transgenic mouse studies indicate that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Several alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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