Thermo Fisher Scientific amyloid Polyclonal Antibody
Thermo Fisher Scientific의 Amyloid 폴리클로날 항체는 인간 및 마우스 반응성을 가지며 Western blot, IHC, ELISA, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 알츠하이머 관련 아밀로이드 베타 단백질 연구에 활용됩니다.
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- 500-11284
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
| Immunoprecipitation (IP) | 2–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the N-terminus of amyloid protein (beta Amyloid, UniProt ID: P05067-1, antigen range 1–770) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human brain tissue
- Cellular location: Cell membrane
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and -2, and nicastrin, which modulates amyloid beta peptide production. Abeta forms extracellular filamentous deposits found in amyloid cores, neuritic plaques, and neurofibrillary tangles.
Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 500-11284_beta_Amyloid_P05067-1_Rabbit.svg, 500-11284_beta_Amyloid_P05067-1_Rabbit_PDP.jpeg)
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