Thermo Fisher Scientific Bcl-2a Monoclonal Antibody (100)
Human Bcl-2a 단백질을 인식하는 Mouse monoclonal 항체. Western blot, IHC, ICC, IP 등 다양한 응용에 적합. Protein A 정제 및 PBS buffer에 안정화되어 있으며, 세포 내 항아포토시스 연구에 유용.
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- 500-1124ABBOMAX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | 2–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 100 |
| Immunogen | Synthetic peptide derived from internal sequence (40–55aa) of human BCL-2 oncoprotein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Tonsil
- Cellular location: Cytoplasmic
Target Information
Bcl-2 related Protein A1 is a member of the BCL-2 protein family. These proteins form hetero- or homodimers and act as anti- and pro-apoptotic regulators involved in diverse cellular processes such as embryonic development, homeostasis, and tumorigenesis. The encoded protein reduces the release of pro-apoptotic cytochrome c from mitochondria and blocks caspase activation. It is a direct transcription target of NF-kappa B in response to inflammatory mediators and is up-regulated by extracellular signals such as GM-CSF, CD40, phorbol ester, TNF, and IL-1, suggesting a cytoprotective role essential for lymphocyte activation and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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