Thermo Fisher Scientific RASA4 Polyclonal Antibody
RASA4 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. IHC(P)에서 1:10~1:50 희석 비율로 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human RAS p21 protein activator 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636232 |
Product Specific Information
This antibody detects endogenous levels of total RASA4 protein.
Target Information
The RASA4 gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/MAPK pathway in response to Ca²⁺. When intracellular Ca²⁺ levels increase, this protein translocates to the plasma membrane, activating Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state, preventing downstream signaling involved in gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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