Thermo Fisher Scientific TPSG1 Monoclonal Antibody (OTI2A10), TrueMAB
TPSG1 단백질을 타깃으로 하는 Mouse IgG1 단일클론 항체. Western blot, ICC/IF, Flow cytometry에 적합. Human 시료 반응성. PBS/BSA/glycerol buffer에 보관되며, -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–283 of human TPSG1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme encoded by the TPSG1 gene in humans. Tryptases belong to the trypsin-like serine protease family (peptidase family S1) and are enzymatically active only as heparin-stabilized tetramers, resistant to endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3, with four functional genes identified: alpha I, beta I, beta II, and gamma I. Variants include alpha II, beta III, and gamma II. Beta tryptases are mainly expressed in mast cells, while alpha-tryptases predominate in basophils. The TPSG1 gene differs from other tryptases by having a C-terminal hydrophobic domain that may act as a membrane anchor. Tryptases are implicated in asthma and other allergic or inflammatory disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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