Thermo Fisher Scientific ALKBH3 Polyclonal Antibody
Rabbit polyclonal antibody against human ALKBH3 protein for ICC/IF applications. Recognizes recombinant ALKBH3, purified by antigen affinity chromatography. Supplied as liquid, unconjugated form in PBS with glycerol. Ideal for research on DNA repair an...
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ALKBH3 (control fragment: Product #RP-106116) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664473 |
Product Specific Information
Immunogen sequence:
NPHWHPVLRTL KNRIEENTGH TFNSLLCNLY RNEKDSVDWH SDDEPSLGRC PIIASLSFGA TRTFEMRKKP PPEENGDYTY VERVKIPLDH GTLLIMEGAT QADWQHRVPK EY
- Highest antigen sequence identity to orthologs: mouse 93%, rat 94%
Target Information
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation.
Has a strong preference for single-stranded DNA.
Processes alkylated 3mC within double-stranded regions via interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3.
May also act on RNA.
Requires molecular oxygen, alpha-ketoglutarate, and iron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-65438_ALKBH3_Q96Q83-1_Rabbit.svg, PA5-65438_ALKBH3_Q96Q83-1_Rabbit_PDP.jpeg)
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