Thermo Fisher Scientific NeuN Polyclonal Antibody
NeuN 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 버퍼에 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific NeuN Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 7 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human NeuN. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.47 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736206 |
Product Specific Information
- Positive Control: Mouse retina, mouse brain, rat brain
- Predicted Reactivity: Human (100%), Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Fox-3, also known as NeuN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain.
Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Two key tumor suppressor genes are associated with chromosome 17: p53 and BRCA1.
- p53: Maintains genetic integrity by moderating DNA repair vs. cell death. Loss or malfunction is linked to malignant cell growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and recognized as a determinant of early onset breast cancer and predisposition to various cancers (ovary, colon, prostate, fallopian tubes).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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