Thermo Fisher Scientific USP28 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
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Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:25–1:100
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Product Specifications

Product Specific Information

This antibody detects endogenous levels of total USP28 protein.

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread and conserved across evolution. They release ubiquitin from conjugated proteins and possess conserved catalytic domains with Cys and His boxes, while their N- or C-terminal extensions aid in substrate recognition, subcellular localization, and protein-protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.