Thermo Fisher Scientific NSD1 Polyclonal Antibody
인간 NSD1/KMT3B 단백질을 검출하는 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC, ChIP 등 다양한 응용에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, PBS 기반의 안정적 저장 용액을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ChIP assay (ChIP) | 2.5 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human nuclear receptor binding SET domain protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636309 |
Product Specific Information
This antibody detects endogenous levels of total NSD1 / KMT3B protein.
Target Information
This gene encodes a protein containing a SET domain, two LXXLL motifs, three nuclear translocation signals (NLSs), four plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, which can be further increased in the presence of other AR-associated coregulators. It may act as a nucleus-localized transcriptional factor and bifunctional transcriptional regulator. Mutations in this gene are associated with Sotos syndrome and Weaver syndrome. A cryptic translocation involving this gene and NUP98 on chromosome 11 has been linked to a form of childhood acute myeloid leukemia. Two transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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