Thermo Fisher Scientific UBQLN4/CIP75/Ubiquilin 4 Recombinant Rabbit Monoclonal Antibody (BLR145J)
Thermo Fisher의 UBQLN4/CIP75/Ubiquilin 4 항체는 인간 단백질을 인식하는 재조합 토끼 단클론 항체입니다. Western blot, IHC, ICC, IP 등 다양한 응용에 적합하며, 고순도 정제된 액상 형태로 제공됩니다. 단백질 분해 연구 및 유비퀴틴-프로테아좀 경로 분석에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR145J |
| Immunogen | Recombinant protein representing Human Ubiquilin-4 (residues 2–601) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ubiquitin-proteasome pathway of protein degradation ensures proper cellular protein levels. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain-containing protein family is involved in proteasomal degradation.
CIP75, also known as ubiquilin-4, interacts with proteins such as Ataxin-1 and Connexin-43, increasing their turnover rate. Overexpression of CIP75 reduces Connexin-43 half-life, while siRNA knockdown has the opposite effect.
CIP75 contains an N-terminal UbL domain that interacts with the 26S proteasome complex and a C-terminal UBA domain that mediates interaction with Connexin-75. At least three isoforms of CIP75 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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