Thermo Fisher Scientific Cortactin Polyclonal Antibody
Cortactin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태로 항원 친화 크로마토그래피 정제. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific Cortactin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–276 of Human Cortactin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.28 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547273 |
Product Specific Information
- Recommended positive controls: HeLa, Neuro 2A, C8D30, NIH-3T3, C2C12, PC-12, Rat2, mouse brain, rat brain
- Predicted reactivity: Mouse (98%), Rat (99%), Chicken (93%), Rhesus Monkey (100%), Bovine (85%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cortactin (Cttn) is a ubiquitous actin-binding protein originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape, and plays a role in lamellipodia formation and cell migration. Cortactin accumulates in actin-enriched cellular structures, facilitating actin network formation.
It contains four major domains: N-terminal acidic (NTA), tandem repeats, proline-rich, and SH3 domains. NTA associates with Arp2/3 and WASP complexes at F-actin branches. Cortactin promotes cell motility and invasion, particularly in invadopodia involved in ECM degradation by cancer cells. It is phosphorylated by Src family kinases at Y421, Y466, Y482 and by Erk family kinases at S405 and S418.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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