Thermo Fisher Scientific PLSCR1 Polyclonal Antibody
PLSCR1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 시료 반응성. 고순도 Affinity 정제 및 안정적 액상 형태로 제공되며, 세포막 및 핵 위치 단백질 분석에 적합.
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Thermo Fisher Scientific PLSCR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within N-terminal human Scramblase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913345 |
Product Specific Information
- Positive Control: 293 cell lysates, HUVEC, human tonsil tissue
- Subcellular Location: Cell membrane, Nucleus, Membrane, Cytoplasm, perinuclear region
Target Information
PLSCR1 (Phospholipid Scramblase 1) is a calcium-dependent plasma membrane protein that facilitates transbilayer movement of phosphatidylserine and other phospholipids following cytosolic calcium influx. This process remodels plasma membrane phospholipids and exposes phosphatidylserine on the surface of apoptotic or injured cells, leading to cell death. PLSCR1 expression is induced by interferons and cytokines, suggesting a role in cytokine signaling pathways. EGF stimulation causes tyrosine phosphorylation at residues 69 and 74, enabling interaction with Shc and linking Src kinase activation to EGF receptor signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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