Thermo Fisher Scientific KCNH2 Polyclonal Antibody
Thermo Fisher Scientific의 KCNH2 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 WB 및 IHC(P) 실험에 적합합니다. 합성 펩타이드 항원으로 제작된 비결합형 항체로, 장기 보관 시 -20°C에서 안정적으로 유지됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:3,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 1120–1162 of mouse KCNH2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and human.
- Specificity of this antibody: KCNS2.
Target Information
Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr.
There are two N-terminal splice variants of HERG: the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1 alpha.
Residues within the C-terminal play a role in channel expression and gating, including voltage-dependent activation.
HERG is expressed in the heart, more abundantly in ventricles than atria.
Mutations in HERG increase beat-to-beat variability and early after depolarization, contributing to long QT syndrome type 2 and short QT syndrome type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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