Thermo Fisher Scientific CYP2B6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human CYP2B6 (NP_0007581) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP2B6,uniProtId:P20813-1,ncbiNodeId:9606,antigenRange:160-340,antigenLength:491,antigenImageFileName:PA5-89950_CYP2B6_P20813-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89950_CYP2B6_P20813-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805861

Product Specific Information

Immunogen sequence: SKGALMDPTF LFQSITANII CSIVFGKRFH YQDQEFLKML NLFYQTFSLI SSVFGQLFEL FSGFLKYFPG AHRQVYKNLQ EINAYIGHSV EKHRETLDPS APKDLIDTYL LHMEKEKSNA HSEFSHQNLN LNTLSLFFAG TETTSTTLRY GFLLMLKYPH VAERVYREIE QVIGPHRPPE L; Positive Samples: NCI-H460, HT-29, Mouse liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein

Target Information

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.