Thermo Fisher Scientific HCN2 Polyclonal Antibody, Atto 594

Applications

• Immunohistochemistry (IHC): Assay-dependent

Product Specifications

Product Specific Information

• Reconstitution: 50 µL double distilled water (DDW), depending on sample size
• Ships as a lyophilized powder at room temperature; store at -20°C upon arrival
• Reconstituted solution can be stored at 4°C for up to 1 week
• For long-term storage, aliquot and store at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

Hyperpolarization-activated cation channels of the HCN gene family, including HCN2, contribute to spontaneous rhythmic activity in both heart and brain.
HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides.
HCN1 and HCN2 are important for motor learning and neuronal integration by cerebellar Purkinje cells, as well as shaping autonomous neuronal activity and network oscillation periodicity.
HCN1 expression is enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus.
HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body.
These regional variations in HCN channel expression contribute to differences in neuronal pacemaker activity across brain systems.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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