Thermo Fisher Scientific slo beta 1 (KCNMB1) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
• Storage: Ships as lyophilized powder at room temperature. Store at -20°C upon arrival.
• Reconstituted Solution: Store at 4°C for up to 1 week. For long-term storage, aliquot and keep at -20°C.
• Handling: Avoid multiple freeze/thaw cycles. Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

Potassium channels are widely expressed proteins that play critical roles in both excitable and non-excitable cells. The large conductance, calcium-activated potassium channel (Maxi K⁺) is unique among potassium channels as its activation is controlled by both intracellular calcium levels and membrane depolarization.

The core Maxi K⁺ channel is a homotetrameric alpha subunit containing a voltage sensor and calcium-binding domain. In vascular smooth muscle, a beta-subunit forms a 1:1 complex with the alpha subunit, reducing the calcium concentration required for channel activation by 5- to 10-fold.

Because of its regulatory role in blood flow and blood pressure, the Maxi K⁺ beta subunit (KCNMB1) is a potential therapeutic target.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.