Thermo Fisher Scientific RGS14 Polyclonal Antibody
상품 옵션 정보 | ||||||||
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
OSR00378W-100UL | - | Thermo Fisher Scientific OSR00378W-100UL RGS14 Polyclonal Antibody 100 ul pk | 재고문의 | pk | 565,000원 | - | 621,500원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
1:300-1:2,000
Immunohistochemistry (IHC)
1:300-1:2,000
Miscellaneous PubMed (Misc)
-
View 1 publication 1 publication
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit / Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 380-430 of human RGS14 conjugated to an immunogenic carrier protein was used as the antigen if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
RGS14,
uniProtId:
O43566-7,
ncbiNodeId:
9606,
antigenRange:
380-430,
antigenLength:
566,
antigenImageFileName:
OSR00378W-100UL_RGS14_O43566-7_Rabbit.svg,
antigenImageFileNamePDP:
OSR00378W-100UL_RGS14_O43566-7_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide shares 98% identity with rat and mouse sequences.
Specificity of this antibody: RGS14.
Target Information
RGS14 is a member of the regulator of G-protein signaling family which contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. RGS14 attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. The resulting hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of RGS14 have been observed but have not been thoroughly characterized. Further, RGS14 acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism; plays a role in cell division; is required for the nerve growth factor (NGF)-mediated neurite outgrowth, and is involved in stress resistance. RGS14 protein may also be involved in visual memory processing capacity and hippocampal-based learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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