Thermo Fisher Scientific GKN1 Polyclonal Antibody
Thermo Fisher Scientific의 GKN1 Polyclonal Antibody는 사람과 마우스 시료에 반응하는 Sheep IgG 항체입니다. Western blot 및 IHC(F/P)에서 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, PBS와 트레할로스 완충액에 재구성하여 사용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–15 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse Gastrokine 1 (Tyr38–Tyr201) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2577022 |
Product Specific Information
- In direct ELISAs, approximately 10% cross-reactivity with recombinant human Gastrokine 1 is observed.
- Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Gastrokine 1 (GKN1, also known as CA11) is a 185-amino-acid secreted protein belonging to the gastrokine family, characterized by a BRICHOS domain and an asparagine-rich region.
GKN1 functions as an antioncogene and is reported to be down-regulated in human gastric cancer tissue compared to normal gastric mucosa.
It is predominantly expressed in the stomach and co-secreted with mucins, acting as a signaling growth factor with mitogenic activity that may help maintain gastric mucosal integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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