Thermo Fisher Scientific IL-6 Monoclonal Antibody (MQ2-13A5), Alexa Fluor 700, eBioscience
인간 IL-6를 인식하는 MQ2-13A5 단클론 항체로, Alexa Fluor 700으로 표지되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 염증 및 면역 관련 연구에 적합합니다. 4°C 어둠 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.06 µg)/test | 5 publications |
| ELISA | - | 2 publications |
| T-Cell Activation (TCA) | - | 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Published Species | Human |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), Alexa Fluor™ 700, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MQ2-13A5 |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_1548819 |
Available Formats
- Unconjugated
- APC
- eFluor 450
- FITC
- Functional Grade
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Custom conjugation available
Product Specific Information
The MQ2-13A5 antibody reacts with human interleukin-6 (IL-6), a 21–28 kDa cytokine secreted by various cell types.
Applications Reported:
This antibody is reported for use in intracellular staining followed by flow cytometric analysis.
Applications Tested:
Pre-titrated and validated for intracellular staining and flow cytometric analysis of stimulated normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (Product #88-8824-00) and corresponding BestProtocols® (Protocol A: Two-step protocol for cytoplasmic intracellular proteins).
Recommended usage: 5 µL (0.06 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Fluorochrome Information:
Alexa Fluor® 700 emits at 723 nm and is excited by the red laser (633 nm).
Recommended optics: 685 LP mirror and 710/20 filter.
Excitation: 633–647 nm; Emission: 723 nm; Laser: Red.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IL-6 encodes a cytokine involved in inflammation and B cell maturation. It acts as an endogenous pyrogen, inducing fever in autoimmune or infectious conditions.
Expression occurs at sites of acute and chronic inflammation, where IL-6 stimulates transcriptional inflammatory responses through the IL-6 receptor alpha.
IL-6 function is linked to multiple inflammation-associated diseases, including diabetes mellitus, systemic juvenile rheumatoid arthritis, Kaposi sarcoma, and rheumatoid arthritis.
Elevated IL-6 levels have been observed in viral infections, including COVID-19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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