Thermo Fisher Scientific HER-4/ERBB4 Monoclonal Antibody (ERBB4/2581)
HER4/ERBB4 단클론 항체(ERBB4/2581)는 인간 ERBB4 단백질을 인식하며 면역조직화학(IHC)과 펩타이드 어레이에 사용됩니다. 단클론 Mouse IgG1 형식으로, PBS 버퍼에 보존제 없이 제공되며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ERBB4/2581 |
| Immunogen | Recombinant fragment (around aa 1116–1269) of human ERBB4 (HER4) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily, which includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing cellular responses such as mitogenesis and differentiation.
It mediates tyrosine phosphorylation and signal transduction processes regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation.
ERBB4 is predominantly expressed in several breast carcinoma cell lines and normal tissues including skeletal muscle, heart, pituitary, brain, and cerebellum.
High expression levels are observed in T47-D, MDA-MB-453, BT-474, and H3396 cell lines, while lower expression is seen in MCF-7, MDAMB-330, and MDA-MB-361.
Expression is low or absent in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3 cell lines.
Elevated ERBB4 levels have been found in certain human tumor cell lines, suggesting a possible role in malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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