Thermo Fisher Scientific DNMT3A Polyclonal Antibody
DNMT3A 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | |
| Immunohistochemistry (IHC) | 1:500–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 | Epitope retrieval with citrate buffer pH 6.0 recommended for FFPE sections |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 125–175 of human DNA (cytosine-5)-Methyltransferase 3 Alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting, and is essential for mammalian development.
Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with cancer development.
Three families of mammalian DNA methyltransferase genes have been identified: Dnmt1, Dnmt2, and Dnmt3.
- Dnmt1: Constitutively expressed in proliferating cells; its inactivation causes global demethylation and embryonic lethality.
- Dnmt2: Expressed at low levels in adult tissues; inactivation does not affect DNA methylation maintenance.
- Dnmt3 family (Dnmt3a, Dnmt3b): Strongly expressed in ES cells, downregulated upon differentiation, and low in adult somatic tissues.
Mutations in the Dnmt3b gene are associated with ICF syndrome (immunodeficiency, centromeric instability, and facial anomalies).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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