Thermo Fisher Scientific FGFR1 Recombinant Rabbit Monoclonal Antibody (SD08-25)
FGFR1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 면역세포염색(ICC/IF)에 적합. 높은 특이성과 재현성을 제공하며, 로트 간 일관성이 우수. 단백질 A로 정제된 액상형 항체로, 장기 보관 시 -20°C에서 안정적.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD08-25 |
| Immunogen | Synthetic peptide within Human FGFR1 (aa 766–822) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809663 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor (FGFR) family, consisting of four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity receptors for 17 fibroblast growth factors (FGF1–17).
The FGFR family plays critical roles in:
- Mesoderm induction and patterning
- Cell growth and migration
- Organ formation and bone growth
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic development and adulthood.
Mutations or defects in FGFR1 are associated with several disorders, including:
- Pfeiffer syndrome (PS)
- Idiopathic hypogonadotropic hypogonadism (IHH)
- Kallmann syndrome type 2 (KAL2)
- Osteoglophonic dysplasia (OGD)
- Non-syndromic trigonocephaly
- Jackson-Weiss syndrome
- Antley-Bixler syndrome
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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