Thermo Fisher Scientific JNK3 Recombinant Rabbit Monoclonal Antibody (SD082-09)
JNK3 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, 높은 특이성과 일관된 로트 간 재현성을 제공합니다. Western blot, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, 동물 유래 성분이 없는 포뮬레이션으로 안정적인 연구용 시약입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD082-09 |
| Immunogen | Synthetic peptide within Human JNK3 aa 401–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809667 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs) involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases serve as integration points for multiple biochemical signals and participate in cellular processes such as proliferation, differentiation, transcription regulation, and development.
This kinase plays regulatory roles during neuronal apoptosis through phosphorylation and nuclear localization. Beta-arrestin 2 interacts with and stimulates phosphorylation of JNK3 by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit JNK3 activity, potentially preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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