Thermo Fisher Scientific DAXX (Transcriptional Corepressor) Monoclonal Antibody (PCRP-DAXX-6A8)

Thermo Fisher Scientific DAXX (Transcriptional Corepressor) Monoclonal Antibody (PCRP-DAXX-6A8)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Antibody is stable for 24 months.
• Positive Control: HeLa or U87 cells.
• Expression: Ubiquitous tissue expression.
• Cellular Localization: Nucleus and Cytoplasm.

Specificity Comments:
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, the protein functions as a transcriptional repressor that binds to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli. The protein also associates with centromeres in G2 phase. In the cytoplasm, it may regulate apoptosis. Subcellular localization and function are modulated by post-translational modifications including sumoylation, phosphorylation, and polyubiquitination. Alternative splicing results in multiple transcript variants.

Target Information

This gene encodes a multifunctional protein that resides in both nucleus and cytoplasm. It interacts with apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, it acts as a transcriptional repressor binding sumoylated transcription factors, with repression relieved by sequestration into nuclear bodies or nucleoli. It associates with centromeres during G2 phase and may regulate apoptosis in the cytoplasm. Function is modulated by post-translational modifications such as sumoylation, phosphorylation, and polyubiquitination. Multiple transcript variants are produced via alternative splicing.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.