Thermo Fisher Scientific LDL receptor Polyclonal Antibody
Thermo Fisher Scientific의 LDL receptor Polyclonal Antibody는 인간, 마우스, 랫드 등 다양한 종에 반응하며 Western blot, IHC, Flow cytometry, ELISA에 사용 가능합니다. Protein A로 정제된 액상 항체로, -20°C에서 보관하며 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Plant, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human LDL-R, amino acids 781–860 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is bound at the cell membrane and internalized into lysosomes, where the protein is degraded and cholesterol becomes available for regulation of HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Mutations in the LDL-R gene cause familial hypercholesterolemia. Along with SCARB1, CLDN1, and CD81, LDL-R is also reported as an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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