Thermo Fisher Scientific GRAMD4 (Transcription Factor) Monoclonal Antibody (PCRP-GRAMD4-1A10)
GRAMD4 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. 면역세포염색(ICC/IF), 유세포분석(Flow Cytometry), 펩타이드 어레이 등에 사용 가능합니다. 단백질 A/G로 정제된 액상 형태이며, 보존제 없이 PBS에 용해되어 있습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-GRAMD4-1A10 |
| Immunogen | Recombinant full-length human GRAMD4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Product Specific Information
Predicted to react in Rat.
Target Information
GRAMD4, also known as Death Inducing Protein, is a 578 amino acid protein containing one GRAM domain. It is a multi-pass membrane protein localized to the mitochondrial membrane. Overexpression of GRAMD4 induces a strong apoptotic response through caspase-3 activation and PARP cleavage. GRAMD4 is expressed in lung tissue and primary lung squamous cell carcinoma (LSCC), showing up-regulation in mitochondria by E2F-1 after 4-hydroxytamoxifen treatment. This suggests GRAMD4 may serve as a potential target for cancer therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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