Thermo Fisher Scientific C17orf85 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:10,000–1:25,000

Immunoprecipitation (IP)

• Tested Dilution: 50–100 µL/mg of lysate

Product Specifications

Target Information

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as an adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger RNA (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA, thereby playing a role only in mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections, and the NCBP3 activity is critical to inhibit virus growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.