Thermo Fisher Scientific MST2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, THP-1, NCI-H929, 293T mock, 293T transfected STK3.
• Predicted reactivity: Mouse (91%), Rat (93%), Xenopus laevis (86%), Chicken (94%), Rhesus Monkey (99%), Bovine (99%).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways. It is activated by proapoptotic stimuli such as staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase that, following caspase cleavage, enters the nucleus to induce chromatin condensation and DNA fragmentation.

It is a key component of the Hippo signaling pathway, which regulates organ size and tumor suppression by restricting proliferation and promoting apoptosis. In this pathway, STK3/MST2 and STK4/MST1, with SAV1, phosphorylate and activate LATS1/2 and MOB1, which in turn phosphorylate and inactivate YAP1 and WWTR1/TAZ. This phosphorylation prevents YAP1 nuclear translocation, thereby regulating genes involved in proliferation, cell death, and migration.

STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.