Thermo Fisher Scientific HSD3B2 Polyclonal Antibody
HSD3B2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Human과 Mouse 시료에 반응합니다. Western blot과 ELISA에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human HSD3B1 + HSD3B2 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720396 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
3 beta-hydroxysteroid dehydrogenase (3β-HSD), also known as HSD3B1 or HSD3B2, is a bifunctional enzyme essential for the synthesis of all classes of hormonal steroids. Two human 3β-HSD proteins, type I (HSD3B1) and type II (HSD3B2), are encoded by different genes and function in distinct tissues. The type I enzyme is localized to the endoplasmic reticulum membrane and expressed in skin and placenta. It catalyzes the oxidative conversion of Δ5-ene-3β-hydroxy steroids and various ketosteroids. Defects in the gene encoding 3β-HSD are associated with conditions such as classic salt wasting, genital ambiguity, hypogonadism, insulin-resistant polycystic ovary syndrome (PCOS), and increased susceptibility to prostate cancer. Congenital deficiency of 3β-HSD activity can cause severe steroid depletion, which may be lethal in young children.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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