Thermo Fisher Scientific TNFR1 Polyclonal Antibody
TNFR1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western Blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 고순도 Affinity Chromatography 정제, 액상 형태로 -20°C 보관.
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- PA5120358
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Thermo Fisher Scientific TNFR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 345–455 of human TNFR1/TNFRSF1A (NP_001056.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.97 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913930 |
Product Specific Information
Positive test controls include: A-549, Rat kidney.
Target locations: Cell membrane, Golgi apparatus membrane, Secreted, Single-pass type I membrane protein.
Immunogen sequence:
AHKPQSLDTD DPATLYAVVE NVPPLRWKEF VRRLGLSDHE IDRLELQNGR CLREAQYSML ATWRRRTPRR EATLELLGRV LRDMDLLGCL EDIEEALCGP AALPPAPSLL R
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors.
It plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 is released into circulation as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12.
Regulatory interactions occur with BAG4/SODD, TRADD, and TRAF2 proteins, influencing receptor-mediated signal transduction.
Mutations of the extracellular domain are associated with autosomal dominant periodic fever syndrome, due to impaired receptor clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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