Thermo Fisher Scientific GPR65 Polyclonal Antibody

Applications

Tested Dilution

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
ETGRYDMWNIL KFCTGRCNTS QRQRKRILSV STKDTMELEV

Highest antigen sequence identity to the following orthologs:

• Mouse: 61%
• Rat: 63%

Target Information

GPR65 (also known as TDAG8) is a transmembrane protein belonging to the G protein-coupled receptor (GPCR) superfamily.
It has 337 amino acids and shows 90% similarity and 81% identity in the seven transmembrane domains of its mouse homolog.
This receptor contains three potential N-linked glycosylation sites and is predominantly expressed in lymphoid organs and cancer tissues. Expression increases during activation-induced death of T-cell hybridomas.

Two major transcripts (4.5 kb and 1.8 kb) are found in peripheral blood leukocytes. GPR65 functions as a proton-sensing receptor, coupling to adenylyl cyclase and psychosine, and plays a role in immunological autotolerance. It is also involved in cellular transformation via RhoA activation and actin rearrangement under acidic conditions.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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