Thermo Fisher Scientific GPR65 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GPR65 for ICC/IF applications. Recognizes recombinant GPR65 antigen, purified via antigen affinity chromatography. Supplied as liquid form, unconjugated, with high specificity for lymphoid and cancer tissue st...
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Applications
Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human GPR65 (control fragment Product #RP-106544) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.09 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663995 |
Product Specific Information
Immunogen sequence:
ETGRYDMWNIL KFCTGRCNTS QRQRKRILSV STKDTMELEV
Highest antigen sequence identity to the following orthologs:
- Mouse: 61%
- Rat: 63%
Target Information
GPR65 (also known as TDAG8) is a transmembrane protein belonging to the G protein-coupled receptor (GPCR) superfamily.
It has 337 amino acids and shows 90% similarity and 81% identity in the seven transmembrane domains of its mouse homolog.
This receptor contains three potential N-linked glycosylation sites and is predominantly expressed in lymphoid organs and cancer tissues. Expression increases during activation-induced death of T-cell hybridomas.
Two major transcripts (4.5 kb and 1.8 kb) are found in peripheral blood leukocytes. GPR65 functions as a proton-sensing receptor, coupling to adenylyl cyclase and psychosine, and plays a role in immunological autotolerance. It is also involved in cellular transformation via RhoA activation and actin rearrangement under acidic conditions.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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