Thermo Fisher Scientific NFkB p52/p100 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive test controls include: HeLa, MCF7, NIH/3T3, C6, Mouse thymus.
The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence:
GHTPLDLTCS TKVKTLLLNA AQNTMEPPLT PPSPAGPGLS LGDTALQNLE QLLDGPEAQG SWAELAERLG LRSLVDTYRQ TTSPSGSLLR SYELAGGDLA GLLEALSDMG LEEGVRLLRG PETRDKLPST AEVKEDSAYG SQSVEQEAEK LGPPPEPPGG LCHGHPQPQV H

Target Information

The NFkB transcription factor was originally identified as a protein complex consisting of a DNA binding subunit and an associated protein. The subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105.
A cDNA has been isolated that encodes an alternative DNA binding subunit of NFkB. It is synthesized as a protein that is expressed in a variety of cell types and, like p105, undergoes cleavage to generate its NFkB subunit, in this case a protein designated p52 (previously referred to as p49).
In contrast to p50 derived from p105, p52 acts in synergy with p65 to stimulate the HIV enhancer in transiently transfected Jurkat cells.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.