Thermo Fisher Scientific TrkB Polyclonal Antibody

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, keep aliquots at -20 °C for higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

NTRK2 (TrkB) belongs to the neurotrophic factor family involved in the development and maintenance of the mammalian nervous system. It serves as the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is a tyrosine kinase receptor expressed mainly in the central and peripheral nervous systems. Upon neurotrophin binding, TrkB phosphorylates itself and members of the MAPK pathway, leading to cell differentiation. Mutations in TrkB have been associated with obesity and mood disorders. Alternative splice variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.